Many men have normal semen reports but still face repeated IVF failures, miscarriages, or unexplained infertility. In such cases, the problem may lie deep inside the sperm DNA; something not visible in a routine semen analysis. Even when sperm count and motility are normal, sperm DNA damage can lead to failed IVF cycles, poor embryo quality, or miscarriages. That’s why we offer DNA Fragmentation Index (DFI) testing.
DFI testing is recommended in cases of repeated IVF or IUI failures, recurrent miscarriages, unexplained infertility, male age over 40, lifestyle risks like smoking or stress, and conditions such as varicocele, obesity, or diabetes. A high DFI can lead to poor embryo development or failed implantation, and knowing your score can guide treatment choices like using testicular sperm, starting antioxidant therapy, or opting for advanced sperm selection methods like PICSI.
- Single-Strand DNA Fragmentation: Often Overlooked, But Important
This test checks for breaks in just one strand of the sperm’s DNA. These breaks are usually caused by factors like smoking, exposure to heat, stress, varicocele, infections, or environmental toxins. A DNA fragmentation score higher than 19% is considered elevated and may lead to issues like poor embryo development, failed implantation, or miscarriage.
This test is especially recommended for:
- Men of advanced age
- Couples facing repeated IUI failures
- Cases where sperm morphology is abnormal (especially when the Teratozoospermia Index or TZI is high)
The good news is that with antioxidant supplements, lifestyle changes, and proper guidance, DNA quality can improve. After 3–6 months of treatment, the test can be repeated to track progress and adjust the treatment plan accordingly.
- Double-Strand DNA Fragmentation: Only at Khushhi IVF
At Khushhi IVF, we’re proud to be the first and only fertility center in India to introduce a highly advanced test that checks for double-strand breaks in sperm DNA– a far more serious form of damage that can deeply affect fertility outcomes.
Double-strand breaks are difficult for the body to repair and are linked to:
- Repeated IVF or ICSI failures, even with good embryos
- Embryo arrest (where development stops suddenly)
- Unexplained infertility
- Early miscarriages
A high level of this damage is considered significant. Early detection allows us to take action before starting another IVF or ICSI cycle. Depending on the results, our specialists may recommend:
- Using testicular sperm instead of ejaculated sperm, as it often has less DNA damage
- Advanced sperm selection methods like PICSI or MACS, which help pick the healthiest sperm
- Adjusting to more targeted IVF protocols for better success
This advanced DNA fragmentation test gives hope to couples who’ve tried everything but haven’t found answers. It uncovers hidden issues that regular tests can miss and allows for a more personalized, informed fertility treatment plan.
- Specialized Male Fertility Treatments Offered at Khushhi IVF
Once the problem is identified, the right treatment plan can begin. At Khushhi IVF, we offer the full spectrum of male infertility treatments, including:
- Microfluidics Sperm Sorting: A gentle, natural way to select the healthiest sperm.
- PICSI (Physiological ICSI): Selects sperm that are naturally mature and DNA-intact.
- TESA, Micro-TESE, PESA: Surgical sperm retrieval options for men with no sperm in the ejaculate.
- Hormone Testing & Treatment: For low testosterone, high prolactin, or FSH/LH imbalances.
- Antioxidant Supplement Protocols: Based on DNA damage reports, lifestyle, and blood tests.
Each treatment is customized to the couple, based on test results and clinical history. We offer complete diagnosis and personalized treatment for male infertility at Khushhi IVF- one of the few centers in Gujarat with such comprehensive male fertility services.
Begin Your Journey with Confidence
Infertility is never one partner’s issue. Male factor infertility is common, treatable, and should never be ignored. With the right diagnosis and personalized plan, success is possible; and that’s what we’re here for. At Khushhi IVF, we are committed to helping you at every step; whether it’s a simple test, an advanced evaluation, or a specialized treatment. You don’t have to go through this alone- because the path to parenthood should never be one-sided.
Why Choose Khushhi IVF for Male Fertility Testing?
- ✅ Most advanced semen analysis in Ahmedabad using CASA + AI
- ✅ Exclusive R11 double strand DFI testing with the most advanced machine
- ✅ Full range of male fertility services – from testing to treatment
- ✅ Surgical sperm retrieval for azoospermia (TESA, PESA, Micro-TESE)
- ✅ Quick, same-day results with detailed reporting
- ✅ Personalized care from experienced doctors and andrologists
