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Dealing with multiple failed cycles

Embarking on fertility treatment is an emotional rollercoaster filled with hope and resilience. However, facing disappointment from multiple failed cycles can be overwhelming. In this blog, we’ll delve into the challenges of dealing with setbacks in fertility treatment and share ways to handle this complex journey. 

Reasons for Failed IVF Cycles

It’s essential to comprehend why multiple rounds of IVF don’t succeed. It helps doctors create personalized plans to identify the issues and overcome them so that the treatment can succeed. The major causes of IVF failures are listed below: 

Embryo Quality:

Poor embryo quality can result from various issues, such as advanced maternal age, genetic abnormalities, or problems during the fertilization process. 

Uterine Factors:

Issues like uterine abnormalities, scar tissue (adhesions), or inadequate blood flow to the uterus can hinder the implantation process. 

Hormonal Imbalances:

Fluctuations or imbalances in hormones can impact egg development, ovulation, the endometrial lining’s receptivity, and sperm production.

Lifestyle Factors:

Factors such as smoking, excessive alcohol consumption, obesity, and inadequate nutrition can negatively affect egg and sperm quality. 

Male Factor Infertility:

Male factor infertility, including issues with sperm quality, quantity, and morphology, is a common contributor to IVF failures.

Immunological Challenges:

Immunological factors, such as autoimmune disorders or an overactive immune system, can contribute to repeated IVF failures. They can interfere with the implantation process.

Stress and Emotional Well-being:

High levels of stress may lead to hormonal imbalances, affecting reproductive processes. 

Understanding and managing the emotional impact:

Experiencing multiple failed cycles in fertility treatment can evoke a range of emotions, from frustration and sadness to anger and despair. Effective communication between partners is crucial. Sharing feelings, fears, and hopes can strengthen the emotional bond. Attending support groups or therapy sessions together can help alleviate some of the emotional burden.

Exploring Alternative Paths: 

In the face of repeated failures, considering alternative paths becomes necessary. This might involve seeking a second opinion, exploring different treatments, or even thinking about adoption or surrogacy. It’s best to decide together and talk openly about the choices available.

Below, we have briefed you about some of the alternative paths or solutions. Either individually or in combination, these alternative options have proven successful for couples experiencing three or more failed IVF attempts.

Infertility Counseling:

Infertility counseling provides emotional support and guidance for couples facing repeated IVF failures. Professional counselors help navigate emotional challenges, offering coping strategies and a safe space to express feelings. Support groups also help in coping with the emotional impact. 

Uterine Evaluation/Hysterosalpingogram (HSG):

HSG is a diagnostic test that assesses the condition of the uterus and fallopian tubes. Identifying any structural abnormalities helps in addressing issues that might hinder successful implantation.

PGS-Pre-Implantation Genetic Screening:

PGS screens embryos for chromosomal abnormalities before implantation. This process improves the likelihood of selecting genetically healthy embryos, reducing the risk of miscarriage and implantation failure.

Endometrial Receptivity Assay (ERA):

ERA determines the best time for embryo transfer by assessing the uterus’s receptivity. This personalized approach improves the chances of implantation, addressing potential factors contributing to failed IVF cycles.

Laser-Assisted Hatching:

This technique involves creating a small opening in the embryo’s outer layer, promoting easier implantation. Laser-assisted hatching is particularly beneficial for embryos with a thick zona pellucida.

Blastocyst Transfer:

Blastocyst transfer involves transferring embryos at a more advanced developmental stage. This increases the chances of implantation, as only embryos with higher developmental potential are selected.

IVF using Donor Eggs/Sperm:

Using donor eggs or sperm can be a successful alternative when there are issues with the quality of the partner’s reproductive cells. This approach has provided a pathway to parenthood for many couples facing repeated IVF failures.


Surrogacy involves another woman carrying and delivering the baby for the intended parents. This option is suitable for couples where carrying a pregnancy to term poses significant challenges.

Self-Care and Emotional Well-being:

Prioritizing self-care is vital. Physical self-care through exercise, a healthy lifestyle, and emotional self-care through mindfulness or enjoyable activities can help. Taking breaks from the fertility journey when needed helps individuals and couples to recharge emotionally and mentally.


Dealing with multiple failed fertility treatment cycles is a significant challenge. The causes behind several failed attempts at IVF are usually complex. Fertility specialists collaborate closely with couples to identify the issues and challenges, tackle underlying issues, and curate intervention plans to enhance the likelihood of a successful IVF journey. 

Individuals and couples can navigate this journey with resilience and hope by addressing the emotional impact, managing expectations, fostering communication, exploring alternatives, and prioritizing self-care.

Khushhi IVF

Khushhi IVF, founded by Dr. Dipesh Sorathiya, brings a wealth of experience with over a decade in fertility treatments, having assisted 10,000+ patients and conducted 5,000+ procedures. Driven by a commitment to provide cutting-edge yet ethical fertility solutions, Khushhi IVF prioritizes an all-encompassing approach that addresses patients’ physical, emotional, and financial needs, while ensuring economical and standardized care.

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